The Use of the Right Antibiotics

Oct 13, 2025 by magicalceylontours.com 110 views

Propionibacterium acnes Resistance Patterns Against Oral Antibiotics in Patients with Vulgaris at H Adam Malik Hospital Medan

Introduction

Acne Vulgaris (AV) is a common skin disease that affects most teenagers and young adults, characterized by the appearance of acne on the face, back, and chest. This disease is caused by inflammation of the hair follicles triggered by various factors, one of which is the bacterium Propionibacterium acnes (PA). PA is a bacterium that lives on the skin and is generally harmless, but under certain conditions, can trigger inflammation that causes acne.

Oral antibiotics, such as doxycycline, minocycline, and erythromycin, are often used to overcome AV by reducing the number of PA bacteria and relieving inflammation. However, over time, PA can develop resistance to antibiotics, so that antibiotics therapy becomes less effective. The increasing resistance of PA to oral antibiotics is a serious concern, as it can lead to the failure of treatment and the emergence of more severe forms of the disease.

Research Background

Research conducted at H Adam Malik Hospital Medan aims to determine the pattern of PA resistance to oral antibiotics in moderate and severe type AV patients. This study involved 43 patients, with 14 men and 29 women, most of whom were less than 25 years old. The study aimed to investigate the prevalence of PA in AV patients and to determine the sensitivity of PA to various oral antibiotics.

Methodology

The study involved a retrospective analysis of medical records of 43 patients with AV who were treated at H Adam Malik Hospital Medan. The patients were selected based on the presence of moderate to severe AV and the availability of culture and sensitivity test results. The study included patients who were treated with oral antibiotics, such as doxycycline, minocycline, and erythromycin.

Results

The results of the study showed that PA was only found in 37.2% of patients. This shows that not all AV cases are caused by the PA, and there may be other factors that play a role in the development of the disease. Of the 16 patients conducted by resistance examination, it was found that the PA was most sensitive to doxycycline and minocycline, with a sensitivity level of 9.38%. Conversely, the PA is most resistant to erythromycin with a resistance rate of 68.7%.

Discussion

The results of this study indicate that PA resistance to antibiotics, especially erythromycin, is increasing. This is a serious concern considering the use of antibiotics that are not appropriate can accelerate the emergence of bacterial resistance. The increasing resistance of PA to oral antibiotics highlights the need for a more strategic approach in AV treatment.

Analysis and Recommendations

Increased PA resistance to oral antibiotics shows the need for a more strategic approach in AV treatment. Some recommendations to consider:

The Use of the Right Antibiotics

The selection of antibiotics must be based on the results of culture and bacterial sensitivity test. Provision of antibiotics appropriately doses and time of treatment can minimize the risk of resistance.

Multi Therapy Approach

The use of combination therapy, such as a combination of antibiotics with topical therapy (topical drugs), can increase the effectiveness of treatment and reduce the risk of resistance.

Prevention and Education

Increasing public awareness about the importance of maintaining skin hygiene, avoiding the use of cosmetics that contain irritants, and avoiding pimples, can help prevent the appearance of AV and reduce the risk of resistance.

Conclusion

It is essential to remember that AV is a complex disease that requires proper and comprehensive treatment. Increased PA resistance to antibiotics is a new challenge in the treatment of AV. Therefore, further research is needed to understand the mechanism of resistance and find effective and safe treatment strategies.

Future Directions

Future studies should focus on investigating the molecular mechanisms of PA resistance to oral antibiotics and developing new treatment strategies that can overcome resistance. Additionally, public awareness campaigns should be implemented to educate patients and healthcare providers about the importance of proper antibiotic use and the risks associated with antibiotic resistance.

Limitations

This study had several limitations, including the small sample size and the retrospective design. Future studies should aim to recruit a larger sample size and use a prospective design to improve the validity of the results.

References

[1] Akhtar, N., & Khan, M. A. (2017). Acne vulgaris: A review. Journal of Clinical and Diagnostic Research, 11(9), OE01-OE04.
[2] Bhattacharya, S. N., & Bhattacharya, S. (2018). Propionibacterium acnes: A review of its role in acne vulgaris. Journal of Clinical and Diagnostic Research, 12(9), OE01-OE04.
[3] Lee, J., & Lee, S. (2019). Antibiotic resistance in Propionibacterium acnes: A review. Journal of Clinical and Diagnostic Research, 13(9), OE01-OE04.

Note: The references provided are fictional and for demonstration purposes only.
Frequently Asked Questions (FAQs) About Propionibacterium Acnes Resistance Patterns Against Oral Antibiotics in Patients with Vulgaris

Q: What is Propionibacterium acnes (PA)?

A: Propionibacterium acnes (PA) is a type of bacteria that lives on the skin and is generally harmless. However, under certain conditions, it can trigger inflammation that causes acne.

Q: What is Acne Vulgaris (AV)?

A: Acne Vulgaris (AV) is a common skin disease that affects most teenagers and young adults, characterized by the appearance of acne on the face, back, and chest.

Q: What are the common oral antibiotics used to treat AV?

A: The common oral antibiotics used to treat AV include doxycycline, minocycline, and erythromycin.

Q: What is the concern about PA resistance to oral antibiotics?

A: The increasing resistance of PA to oral antibiotics is a serious concern, as it can lead to the failure of treatment and the emergence of more severe forms of the disease.

Q: What are the recommendations to overcome PA resistance to oral antibiotics?

A: Some recommendations to consider include:

The use of the right antibiotics, based on the results of culture and bacterial sensitivity test
Multi therapy approach, such as a combination of antibiotics with topical therapy (topical drugs)
Prevention and education, increasing public awareness about the importance of maintaining skin hygiene, avoiding the use of cosmetics that contain irritants, and avoiding pimples

Q: What is the importance of proper antibiotic use?

A: Proper antibiotic use is essential to minimize the risk of resistance and ensure the effectiveness of treatment.

Q: What are the future directions for research on PA resistance to oral antibiotics?

A: Future studies should focus on investigating the molecular mechanisms of PA resistance to oral antibiotics and developing new treatment strategies that can overcome resistance.

Q: What are the limitations of this study?

A: This study had several limitations, including the small sample size and the retrospective design. Future studies should aim to recruit a larger sample size and use a prospective design to improve the validity of the results.

Q: What are the implications of this study for patients and healthcare providers?

A: This study highlights the need for a more strategic approach in AV treatment, including the use of the right antibiotics, multi therapy approach, and prevention and education. Patients and healthcare providers should be aware of the importance of proper antibiotic use and the risks associated with antibiotic resistance.

Q: What are the next steps for further research on PA resistance to oral antibiotics?

A: Further research is needed to understand the mechanism of resistance and find effective and safe treatment strategies. This may involve investigating the molecular mechanisms of PA resistance to oral antibiotics and developing new treatment strategies that can overcome resistance.

Q: What are the potential consequences of PA resistance to oral antibiotics?

A: The potential consequences of PA resistance to oral antibiotics include the failure of treatment, the emergence of more severe forms of the disease, and the spread of antibiotic-resistant bacteria to other parts of the body.

Q: What are the potential benefits of further research on PA resistance to oral antibiotics?

A: The potential benefits of further research on PA resistance to oral antibiotics include the development of new treatment strategies that can overcome resistance, the improvement of treatment outcomes, and the prevention of the spread of antibiotic-resistant bacteria.

Note: The questions and answers provided are fictional and for demonstration purposes only.